Odwala omwe ali ndi vuto la aimpso amafunikira dialysis yokhazikika, yomwe ndi njira yolowera komanso yowopsa.Koma tsopano ofufuza a ku yunivesite ya California, San Francisco (UCSF) asonyeza bwinobwino impso ya prototype bioartificial yomwe ingakhoze kuikidwa ndikugwira ntchito popanda kufunikira kwa mankhwala.
Impso imagwira ntchito zambiri zofunika m'thupi, chodziwika kwambiri ndikusefa poizoni ndi zinyalala m'magazi, komanso kuwongolera kuthamanga kwa magazi, kuchuluka kwa ma electrolyte ndi madzi ena am'thupi.
Choncho, pamene ziwalozi ziyamba kulephera, zimakhala zovuta kwambiri kubwereza njirazi.Odwala nthawi zambiri amayamba ndi dialysis, koma izi zimatenga nthawi komanso zimakhala zosasangalatsa.Njira yothetsera nthawi yayitali ndi kupatsirana kwa impso, komwe kungabwezeretse moyo wapamwamba, koma kumayendera limodzi ndi kufunikira kogwiritsa ntchito mankhwala osokoneza bongo kuti ateteze zotsatira zoopsa za kukana.
Kwa ntchito ya impso ya UCSF, gululo linapanga impso ya bioartificial yomwe imatha kuikidwa mwa odwala kuti azichita ntchito zazikulu za zinthu zenizeni, koma safuna mankhwala oletsa chitetezo cha mthupi kapena ochepetsetsa magazi, omwe nthawi zambiri amafunika.
Chipangizochi chimakhala ndi zigawo ziwiri zazikulu.Sefa yamagazi imapangidwa ndi nembanemba ya silicon semiconductor, yomwe imatha kuchotsa zinyalala m'magazi.Nthawi yomweyo, bioreactor ili ndi maselo opangidwa ndi aimpso a tubular omwe amatha kuwongolera kuchuluka kwa madzi, kuchuluka kwa ma electrolyte ndi ntchito zina za metabolic.Nembanembayo imatetezanso maselowa kuti asawonongedwe ndi chitetezo cha mthupi cha wodwalayo.
Mayesero am'mbuyomu adalola kuti chilichonse mwa zigawozi chizigwira ntchito palokha, koma aka ndi nthawi yoyamba yomwe gulu lidawayesa kuti agwire ntchito limodzi mu chipangizo.
Impso ya bioartificial imalumikizidwa ndi mitsempha ikuluikulu iwiri m'thupi la wodwalayo - imodzi imanyamula magazi osefedwa m'thupi ndipo ina imanyamula magazi osefedwa kubwerera m'thupi - ndi kuchikhodzodzo, komwe zinyalala zimayikidwa ngati mkodzo.
Gululi tsopano lachita kuyesera kwa umboni, kusonyeza kuti impso za bioartificial zimagwira ntchito kokha pansi pa kuthamanga kwa magazi ndipo sizifuna mpope kapena mphamvu yakunja.Maselo amtundu wa aimpso amakhalabe ndi moyo ndipo amapitilirabe kugwira ntchito nthawi yonse yoyezetsa.
Chifukwa cha khama lawo, ofufuza pa yunivesite ya California, San Francisco tsopano alandira mphoto ya KidneyX $ 650,000 monga m'modzi mwa opambana pa gawo loyamba la mphotho ya impso zopanga.
Shuvo Roy, yemwe ndi wofufuza wamkulu pa ntchitoyi, anati: "Gulu lathu linapanga impso yochita kupanga yomwe ingathandize kulima kwa maselo a impso popanda kuchititsa chitetezo cha mthupi."Ndi kuthekera kwa kuphatikiza kwa riyakitala, titha kuyang'ana kwambiri pakukweza ukadaulo kuti tiyesetse mozama kwambiri zachipatala komanso mayeso azachipatala. ”