Ofufuza ochokera ku Dipatimenti ya Mechanical and Aerospace Engineering (MAE) ya Herbert Wertheim School of Engineering apanga mtundu watsopano wa hemodialysis membrane wopangidwa ndi graphene oxide (GO), yomwe ndi monoatomic layered material.Akuyembekezeka kusintha kwathunthu chithandizo cha dialysis ya impso moleza mtima.Kupita patsogolo kumeneku kumapangitsa kuti makina osindikizira a microchip agwirizane ndi khungu la wodwalayo.Kugwira ntchito pansi pa kuthamanga kwa magazi, kumachotsa pampu yamagazi ndi kuzungulira kwamagazi, ndikulola kuti dialysis ikhale yabwino m'nyumba mwanu.Poyerekeza ndi nembanemba wa polima, permeability wa nembanemba ndi madongosolo awiri a ukulu, ali ndi magazi mogwirizana, ndipo si mophweka masikedwe monga polima nembanemba.
Pulofesa Knox T. Millsaps wa MAE komanso wofufuza wamkulu wa polojekiti ya membrane Saeed Moghaddam ndi gulu lake apanga njira yatsopano yodzipangira okha komanso kukhathamiritsa kwa thupi ndi mankhwala a GO nanoplatelets.Izi zimangotembenuza zigawo za 3 GO kukhala ma nanosheet opangidwa mwadongosolo kwambiri, motero amakwaniritsa kukwanira kwapamwamba kwambiri komanso kusankha."Popanga nembanemba yomwe imatha kuloŵa kwambiri kuposa yachilengedwe, glomerular basement membrane (GBM) ya impso, tawonetsa kuthekera kwakukulu kwa ma nanomaterials, nanoengineering, ndi molecular self-assembling."Mogda Dr. Mu adatero.
Kufufuza kwa magwiridwe antchito a membrane muzochitika za hemodialysis kwatulutsa zotsatira zolimbikitsa kwambiri.Ma sieving coefficients a urea ndi cytochrome-c ndi 0.5 ndi 0.4, motero, omwe ndi okwanira kwa nthawi yayitali pang'onopang'ono dialysis pamene akusunga zoposa 99% ya albumin;Kafukufuku wokhudza hemolysis, kutsegulira kowonjezera ndi kukomoka kwawonetsa kuti amafanana ndi zida za dialysis zomwe zilipo kale kapena kuposa momwe zidaliri za dialysis zomwe zilipo kale.Zotsatira za kafukufukuyu zidasindikizidwa pa Advanced Materials Interfaces (February 5, 2021) pansi pa mutu wakuti "Trilayer Interlinked Graphene Oxide Membrane for Wearable Hemodialyzer".
Dr. Moghaddam anati: “Tasonyeza chithunzi chapadera chodzipangira tokha cha GO nanoplatelet oda, chomwe chapititsa patsogolo kwambiri khama la zaka khumi lopanga nembanemba zopangidwa ndi graphene.”Ndi nsanja yothandiza yomwe imatha kupititsa patsogolo dialysis yausiku kunyumba. ”Dr. Moghaddam pakali pano akugwira ntchito yokonza ma microchips pogwiritsa ntchito nembanemba yatsopano ya GO, zomwe zidzabweretsa kafukufuku pafupi ndi zenizeni za kupereka zipangizo zogwiritsira ntchito hemodialysis kwa odwala matenda a impso.
Nkhani ya mkonzi ya Nature (March 2020) inanena kuti: “Bungwe la World Health Organization limati pafupifupi anthu 1.2 miliyoni amafa ndi matenda a impso chaka chilichonse [ndipo matenda obwera chifukwa cha matenda a impso (ESRD) amayamba chifukwa cha matenda a shuga ndi matenda oopsa]….Dialysis Kuphatikizika kwa zoperewera zaukadaulo ndi kukwanitsa kukwanitsa kumatanthauzanso kuti anthu ochepera theka la anthu omwe akufunika chithandizo ndi omwe amapeza chithandizocho. ”Zovala zowoneka bwino zocheperako ndi njira yachuma yowonjezeretsa kupulumuka, makamaka pachitukuko cha China."Nembanemba yathu ndi gawo lofunika kwambiri la kachitidwe kakang'ono kakang'ono, komwe kamatha kuberekanso ntchito yosefera ya impso, ndikuwongolera kwambiri chitonthozo komanso kukwanitsa kukwanitsa padziko lonse lapansi," adatero Dr. Moghaddam.
"Kupita patsogolo kwakukulu kwa chithandizo cha odwala omwe ali ndi hemodialysis ndi kulephera kwaimpso kumachepa ndiukadaulo wa nembanemba.Ukadaulo wamamembrane sunapite patsogolo kwambiri m'zaka makumi angapo zapitazi.Kupita patsogolo kofunikira kwaukadaulo wa nembanemba kumafuna kuwongolera kwa aimpso dialysis.A kwambiri permeable ndi kusankha Zida, monga kopitilira muyeso-woonda graphene okusayidi nembanemba opangidwa pano, akhoza kusintha paradigm.Ma nembanemba owonda kwambiri amatha kuzindikira ma dialyzer ang'onoang'ono, komanso zida zenizeni zonyamulika komanso kuvala, potero zimathandizira kuti moyo ukhale wabwino komanso kulosera kwa odwala. ”James L. McGrath adanena kuti ndi pulofesa wa sayansi ya zamankhwala ku yunivesite ya Rochester komanso woyambitsa teknoloji yatsopano ya silicon yopyapyala kwambiri yogwiritsira ntchito zamoyo zosiyanasiyana (Nature, 2007).
Kafukufukuyu adathandizidwa ndi National Institute of Biomedical Imaging and Bioengineering (NIBIB) pansi pa National Institutes of Health.Gulu la Dr. Moghaddam likuphatikizapo Dr. Richard P. Rode, mnzake wa postdoctoral ku UF MAE, Dr. Thomas R. Gaborski (wofufuza wamkulu), Daniel Ornt, MD (wofufuza wamkulu), ndi Henry C wa Dipatimenti ya Biomedical Engineering, Rochester Institute of Technology.Dr. Chung ndi Hayley N. Miller.
Dr. Moghaddam ndi membala wa UF Interdisciplinary Microsystems Group ndipo amatsogolera Nanostructured Energy Systems Laboratory (NESLabs), yomwe cholinga chake ndi kupititsa patsogolo chidziwitso cha nanoengineering ya zomangamanga zogwirira ntchito ndi micro/nanoscale transmission physics.Amasonkhanitsa maphunziro angapo a uinjiniya ndi sayansi kuti amvetsetse bwino fiziki yapa Micro/nano-scale transmission ndikupanga mapangidwe ndi machitidwe am'badwo wotsatira ndikuchita bwino kwambiri.
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